Spravato is a prescription es-ketamine nasal spray, which is taken alongside an antidepressant.
Esketamine is different from the traditional medications for depression targeting the N-methyl-D-aspartate (NMDA) receptors in the brain, where other common antidepressants do not.
Spravato is used for adults with:
Treatment Resistant Depression
- Major Depressive Disorder with no improvement in symptoms
- Psychological counseling or psychotherapy has not helped
- Symptoms failed to improve with various antidepression medications
Clinical studies show that adults with Treatment-resistant depression who took Spravato and an antidepressant experienced greater reductions of depressive symptoms at four weeks compared to those who received a placebo plus an oral antidepressant.
Major depressive disorder with suicidal thoughts or actions
- Major Depressive Disorder
- Symptoms of Depression which include suicidal thoughts or ideation
- History and/or recent plans to harms one's self or take one's life
Clinical studies of adults with MDD with suicidal thoughts or actions show that those who took Spravato and an antidepressant experienced a greater reduction of depressive symptoms at 24 hours compared to those who took a placebo plus an oral antidepressant.
Our clinic an approved Spravato treatment center
Spravato is available only through a restricted program via REMS approval because of the risk of sedation, dissociation, and abuse/misuse.
Important requirements include the following:
- Healthcare settings must be certified in the program and ensure that Spravato is:
- Only dispensed and administered in healthcare settings.
- Patients treated in outpatient settings (e.g., medical offices and clinics) must be enrolled in the program.
- Administered by patients under the direct observation of a healthcare provider and that patients are monitored by a healthcare provider for at least 2 hours after administration.
If you are looking for help with depression and other treatments have failed, its time to try esketamine or transcranial magnetic stimulation (TMS).
What to expect in a Spravato® Treatment
You’ll need to plan for rides to and from our clinic. Because of possible side effects which can affect mental alertness and motor coordination, you won’t be able to drive, operate machinery or do anything which may require you need to be completely alert until the day after a treatment session, following a night’s sleep.
Some patients bring a book, a relaxing music playlist, or another form of entertainment for the session because your healthcare provider will monitor you for at least two hours after treatment.
There are some patients during the treatment that might experience nausea or vomiting. You should avoid eating at least two hours before and drinking liquids 30 minutes before your treatments.
If you take a nasal corticosteroid or nasal decongestant medicine, take these medicines at least one hour before your treatment.
Understanding Your Insurance's Coverage
Some insurances offer coverage for Spravato (Es-Ketamine). Our team will work closely with your health insurance benefits, manage any necessary pre-authorizations, and ensure you are fully informed about your coverage and costs prior to your appointment.
